Prebiotics Clinical Trials

Prebiotics have been the subject of various clinical trials, documenting many different physiological benefits. 

Watch this space for a database of clinical trials and health indicators studied for various clinical trials. 

In the meantime, the following reviews may be consulted for relevant information.

FOS: Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients. 2022 Aug 12;14(16):3298. doi: 10.3390/nu14163298. PMID: 36014803; PMCID: PMC9413759.

Inulin: Liu X, Yang Q, He Z, Yao S. Efficacy and safety of inulin supplementation for functional constipation: a systematic review protocol. BMJ Open. 2021 Apr 8;11(4):e042597. doi: 10.1136/bmjopen-2020-042597. PMCID: PMC8039257.

GOS: Mei Z, Yuan J, Li D. Biological activity of galacto-oligosaccharides: A review. Front Microbiol. 2022 Sep 6;13:993052. doi: 10.3389/fmicb.2022.993052. PMID: 36147858; PMCID: PMC9485631.

Resistant Starch: Baptista NT, Dessalles R, Illner AK, Ville P, Ribet L, Anton PM, Durand-Dubief M. Harnessing the power of resistant starch: a narrative review of its health impact and processing challenges. Front Nutr. 2024 Mar 20;11:1369950. doi: 10.3389/fnut.2024.1369950. PMID: 38571748; PMCID: PMC10987757.

HMOs: Schönknecht YB, Moreno Tovar MV, Jensen SR, Parschat K. Clinical Studies on the Supplementation of Manufactured Human Milk Oligosaccharides: A Systematic Review. Nutrients. 2023 Aug 17;15(16):3622. doi: 10.3390/nu15163622. PMID: 37630811; PMCID: PMC10458772.

MOS: Asbury RE, Saville BA. Manno-oligosaccharides as a promising antimicrobial strategy: pathogen inhibition and synergistic effects with antibiotics. Front Microbiol. 2025 Mar 24;16:1529081. doi: 10.3389/fmicb.2025.1529081. PMID: 40196030; PMCID: PMC11973258.

XOS: Nogueira-Preito, N-M., A review of the capacity of xylooligosaccharides to modulate gut microbiota and promote health, Food Funct., 2025,16, 4654-4672, doi.org/10.1039/D5FO00169B